Devoting ourselves to the manifestly unattainable*

The Economic Case for Devoting Public Resources to Health

The Economic Case for Devoting Public Resources to Health The world has enjoyed huge improvements in population health during the last half century. But major health problems persist, particularly in tropical countries, which are still struggling with infectious diseases while increasingly having to deal with noncommunicable diseases. Several classic arguments for public spending on health have...

Exposing ourselves to art.

Background: Apolipoprotein B-100 (apo B-100) stands as one of the largest proteins in humans. Its large size of 4536 amino acids hampers the production of X-ray diffraction quality crystals and hinders in-solution NMR analysis, and thus necessitates a domain-based approach for the structural characterization of the multi-domain full-length apo B. Results: The structure of apo B-17 (the N-termin...

Learning to tolerate ourselves

2 JEM Vol. 206, No. 1, 2009 Learning to tolerate ourselves On age 139, Duty et al. find self-reactive B cells in healthy adults that might harm their own body if given the chance. Checkpoints during B cell development ensure that immune cells won’t confuse the self for an intruder. At birth, many B cells express self-reactive receptors. Most of the...

Ourselves

Irradiating Ourselves

Background: Efficient incorporation of the cellular cytidine deaminase APOBEC3G (APO3G) into HIV-1 virions is necessary for its antiviral activity. Even though cellular RNAs are known to be nonspecifically incorporated into virus particles, we have previously found that encapsidation of APO3G into HIV-1 virions is specifically enhanced by viral genomic RNA. Intracellularly, APO3G was found to f...